Leptin receptor signaling inhibits ovarian follicle development and egg laying in chicken hens.

ABSTRACT:

Background

Nutrition intake during growth strongly influences ovarian follicle development and egg laying in chicken hens, yet the underlying endocrine regulatory mechanism is still poorly understood. The relevant research progress is hindered by difficulties in detection of leptin gene and its expression in the chicken. However, a functional leptin receptor (LEPR) is present in the chicken which has been implicated to play a regulatory role in ovarian follicle development and egg laying. The present study targeted LEPR by immunizing against its extracellular domain (ECD), and examined the resultant ovarian follicle development and egg-laying rate in chicken hens.

Methods

Hens that have been immunized four times with chicken LEPR ECD were assessed for their egg laying rate a

SUBMITTER: Lei MM 

PROVIDER: S-EPMC3976635 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature