No association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population.

ABSTRACT:

Objective(s)

Accumulating evidence has demonstrated that miRNAs contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (GC). Recent studies focused on the four single nucleotide polymorphisms (SNPs) of pre-miRNAs including rs11614913, rs3746444, rs2910164, and rs2292832. It was suggested that these four SNPs were significantly associated with the risk of GC and were described as candidate susceptibility factors. However, the previous results show conflicting findings. The aim of this study was to investigate whether these four SNPs are associated with GC in Chinese Han population.

Materials and methods

Genotype frequencies of these four SNPs of pre-miRNAs in 220 GC patients and 530 control subjects were performed using a PCR-RFLP ass

SUBMITTER: Pu JY 

PROVIDER: S-EPMC3976751 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature