Paternal age at childbearing and offspring psychiatric and academic morbidity.

ABSTRACT:

Importance

Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confounding factors.

Objective

To examine the associations between advancing paternal age at childbearing and numerous indexes of offspring morbidity.

Design, setting, and participants

We performed a population-based cohort study of all individuals born in Sweden in 1973-2001 (N = 2,615,081), with subsets of the data used to predict childhood or adolescent morbidity. We estimated the ri

SUBMITTER: D'Onofrio BM 

PROVIDER: S-EPMC3976758 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature