Molecular patterns of neurodevelopmental preconditioning: a study of the effects of antenatal steroid therapy in a protein-restriction mouse model.

ABSTRACT: Introduction. Prenatal programming secondary to maternal protein restriction renders an inherent susceptibility to neural compromise in neonates and any addition of glucocorticosteroids results in further damage. This is an investigation of consequent global gene activity due to effects of antenatal steroid therapy on a protein restriction mouse model. Methods. C57BL/6N pregnant mice were administered control or protein restricted diets and subjected to either 100  μ g/Kg of dexamethasone sodium phosphate with normosaline or normosaline alone during late gestation (E10-E17). Nontreatment groups were also included. Brain samples were collected on embryonic day 17 and analyzed by mRNA microarray analysis. Results. Microarray analyses presented 332 significantly regulated genes. Overall, neur

SUBMITTER: Velayo C 

PROVIDER: S-EPMC3976831 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature