Metatranscriptomics of the human oral microbiome during health and disease.

ABSTRACT: The human microbiome plays important roles in health, but when disrupted, these same indigenous microbes can cause disease. The composition of the microbiome changes during the transition from health to disease; however, these changes are often not conserved among patients. Since microbiome-associated diseases like periodontitis cause similar patient symptoms despite interpatient variability in microbial community composition, we hypothesized that human-associated microbial communities undergo conserved changes in metabolism during disease. Here, we used patient-matched healthy and diseased samples to compare gene expression of 160,000 genes in healthy and diseased periodontal communities. We show that health- and disease-associated communities exhibit defined differences in metabolism tha

SUBMITTER: Jorth P 

PROVIDER: S-EPMC3977359 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature