Association between tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis.

ABSTRACT:

Background

Tumor necrosis factor-alpha (TNF-α) is an important inflammatory cytokine that may play a role in controlling the progression of prostate cancer. Two common polymorphisms in the TNF-α gene, -308G/A and -238C/T, have been suggested to alter the risk for prostate cancer, but the results have been inconclusive so far. In order to obtain a better understanding of the effects of these two polymorphisms on prostate cancer risk, all available studies were considered in a meta-analysis.

Methods

We conducted a comprehensive literature search in the Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature database (CBM), and the China National Knowledge Infrastructure (CNKI). The associations were evaluated by calculating the pooled odds ratio (OR) with 95% confidenc

SUBMITTER: Ma L 

PROVIDER: S-EPMC3977697 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature