Essential role of Apelin signaling during lymphatic development in zebrafish.

ABSTRACT:

Objective

Apelin and its cognate receptor Aplnr/Apj are essential for diverse biological processes. However, the function of Apelin signaling in lymphatic development remains to be identified, despite the preferential expression of Apelin and Aplnr within developing blood and lymphatic endothelial cells in vertebrates. In this report, we aim to delineate the functions of Apelin signaling during lymphatic development.

Approach and results

We investigated the functions of Apelin signaling during lymphatic development using zebrafish embryos and found that attenuation of Apelin signaling substantially decreased the formation of the parachordal vessel and the number of lymphatic endothelial cells within the developing thoracic duct, indicating an essential role of Apelin signali

SUBMITTER: Kim JD 

PROVIDER: S-EPMC3977740 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature