Circadian rhythms: from basic mechanisms to the intensive care unit.

ABSTRACT:

Objective

: Circadian rhythms are intrinsic timekeeping mechanisms that allow for adaptation to cyclic environmental changes. Increasing evidence suggests that circadian rhythms may influence progression of a variety of diseases as well as effectiveness and toxicity of drugs commonly used in the intensive care unit. In this perspective, we provide a brief review of the molecular mechanisms of circadian rhythms and its relevance to critical care. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION, AND DATA SYNTHESIS:: Articles related to circadian rhythms and organ systems in normal and disease conditions were searched through the PubMed library with the goal of providing a concise review.

Conclusions

: Critically ill patients may be highly vulnerable to disruption of circadian r

SUBMITTER: Chan MC 

PROVIDER: S-EPMC3977926 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature