Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.

ABSTRACT: In more than 20% of the world population, sensitization to house dust mite allergens triggers typical allergic diseases such as allergic rhinitis and asthma. Amongst the 23 mite allergen groups hitherto identified, group 1 is cysteine proteases belonging to the papain-like family whereas groups 3, 6, and 9 are serine proteases displaying trypsin, chymotrypsin, and collagenolytic activities, respectively. While these proteases are more likely to be involved in the mite digestive system, they also play critical roles in the initiation and in the chronicity of the allergic response notably through the activation of innate immune pathways. All these allergenic proteases are expressed in mite as inactive precursor form. Until recently, the exact mechanisms of their maturation into active protea

SUBMITTER: Dumez ME 

PROVIDER: S-EPMC3978338 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature