MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer.

ABSTRACT:

Introduction

MicroRNAs are small non-coding RNAs that are involved in the post-transcriptional negative regulation of mRNAs. MicroRNA 510 (miR-510) was initially shown to have a potential oncogenic role in breast cancer by the observation of its elevated levels in human breast tumor samples when compared to matched non-tumor samples. Few targets have been identified for miR-510. However, as microRNAs function through the negative regulation of their direct targets, the identification of those targets is critical for the understanding of their functional role in breast cancer.

Methods

Breast cancer cell lines were transfected with pre-miR-510 or antisense miR-510 and western blotting and quantitative real time PCR were performed. Functional assays performed included cell grow

SUBMITTER: Guo QJ 

PROVIDER: S-EPMC3978419 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature