Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts.

ABSTRACT:

Introduction

Some studies have suggested that night work may be associated with an increased risk of breast cancer in nurses. We aimed to explore the role of circadian gene polymorphisms in the susceptibility to night work-related breast cancer risk.

Methods

We conducted a nested case-control study of Norwegian nurses comprising 563 breast cancer cases and 619 controls within a cohort of 49,402 Norwegian nurses ages 35 to 74 years. We studied 60 single-nucleotide polymorphisms (SNPs) in 17 genes involved in the regulation of the circadian rhythm in cases and controls. The data were analyzed in relation to the two exposure variables "maximum number of consecutive night shifts ever worked" and "maximum number of consecutive night shifts worked for at least 5 years." The odds o

SUBMITTER: Zienolddiny S 

PROVIDER: S-EPMC3978690 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature