A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

ABSTRACT:

Introduction

Chemotherapy-induced alopecia is one of the most common adverse events caused by conventional cytotoxic chemotherapy, yet there has been very little progress in the prevention or treatment of this side effect. Although this is not a life-threatening event, alopecia is very psychologically difficult for many women to manage. In order to improve the quality of life for these women, it is important to elucidate the molecular mechanisms of chemotherapy-induced alopecia and develop ways to effectively prevent and/or treat it. To identify the genetic risk factors associated with chemotherapy-induced alopecia, we conducted a genome-wide association study (GWAS) using DNA samples from breast cancer patients who were treated with chemotherapy.

Methods

We performed a case

SUBMITTER: Chung S 

PROVIDER: S-EPMC3978764 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature