HLA and non-HLA genes in Behcet's disease: a multicentric study in the Spanish population.

ABSTRACT:

Introduction

According to genome wide association (GWA) studies as well as candidate gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of this study were to further investigate the influence of the HLA region in BD and to explore the relationship with non-HLA genes recently described to be associated in other populations.

Methods

This study included 304 BD patients and 313 ethnically matched controls. HLA-A and HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag single nucleotide po

SUBMITTER: Montes-Cano MA 

PROVIDER: S-EPMC3978908 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature