Association between P478S polymorphism of the filaggrin gene & atopic dermatitis.

ABSTRACT:

Background & objectives

Atopic diseases, including atopic dermatitis (AD), allergy and asthma, are complex diseases resulting from the effect of multiple genetic and interacting environmental factors on their pathophysiology. The genetic basis is incompletely understood; however, recent studies have shown an association between loss-of-function variants of the filaggrin gene (FLG) and atopic dermatitis. The aim of this study was to determine whether FLG variants can serve as a predictor for atopic diseases in Korean individuals.

Methods

A total of 648 subjects were genotyped for the FLG P478S (rs11584340, C/T base change) polymorphism (322 patients and 326 controls). Serum levels of free fatty acids (FFA) and IgE were later stratified to determine the effects of the FLG poly

SUBMITTER: Kim SY 

PROVIDER: S-EPMC3978983 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature