Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial.

ABSTRACT:

Background

Lowering of blood pressure prevents stroke but optimum target levels to prevent recurrent stroke are unknown. We investigated the effects of different blood-pressure targets on the rate of recurrent stroke in patients with recent lacunar stroke.

Methods

In this randomised open-label trial, eligible patients lived in North America, Latin America, and Spain and had recent, MRI-defined symptomatic lacunar infarctions. Patients were recruited between March, 2003, and April, 2011, and randomly assigned, according to a two-by-two multifactorial design, to a systolic-blood-pressure target of 130-149 mm Hg or less than 130 mm Hg. The primary endpoint was reduction in all stroke (including ischaemic strokes and intracranial haemorrhages). Analysis was done by intention to

SUBMITTER: SPS3 Study Group 

PROVIDER: S-EPMC3979302 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature