Hydrogen sulfide activation in hemeproteins: the sulfheme scenario.

ABSTRACT: Traditionally known as a toxic gas, hydrogen sulfide (H2S) is now recognized as an important biological molecule involved in numerous physiological functions. Like nitric oxide (NO) and carbon monoxide (CO), H2S is produced endogenously in tissues and cells and can modulate biological processes by acting on target proteins. For example, interaction of H2S with the oxygenated form of human hemoglobin and myoglobin produces a sulfheme protein complex that has been implicated in H2S degradation. The presence of this sulfheme derivative has also been used as a marker for endogenous H2S synthesis and metabolism. Remarkably, human catalases and peroxidases also generate this sulfheme product. In this review, we describe the structural and functional aspects of the sulfheme derivative in these pr

SUBMITTER: Rios-Gonzalez BB 

PROVIDER: S-EPMC3979310 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature