A strategy based on protein-protein interface motifs may help in identifying drug off-targets.

ABSTRACT: Networks are increasingly used to study the impact of drugs at the systems level. From the algorithmic standpoint, a drug can "attack" nodes or edges of a protein-protein interaction network. In this work, we propose a new network strategy, "The Interface Attack", based on protein-protein interfaces. Similar interface architectures can occur between unrelated proteins. Consequently, in principle, a drug that binds to one has a certain probability of binding to others. The interface attack strategy simultaneously removes from the network all interactions that consist of similar interface motifs. This strategy is inspired by network pharmacology and allows inferring potential off-targets. We introduce a network model that we call "Protein Interface and Interaction Network (P2IN)", which is t

SUBMITTER: Engin HB 

PROVIDER: S-EPMC3979525 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature