Bayesian Models for Multiple Outcomes in Domains with Application to the Seychelles Child Development Study.

ABSTRACT: The Seychelles Child Development Study (SCDS) examines the effects of prenatal exposure to methylmercury on the functioning of the central nervous system. The SCDS data include 20 outcomes measured on 9-year old children that can be classified broadly in four outcome classes or "domains": cognition, memory, motor, and social behavior. Previous analyses and scientific theory suggest that these outcomes may belong to more than one of these domains, rather than only a single domain as is frequently assumed for modeling. We present a framework for examining the effects of exposure and other covariates when the outcomes may each belong to more than one domain and where we also want to learn about the assignment of outcomes to domains. Each domain is defined by a sentinel outcome which is preass

SUBMITTER: Xiao L 

PROVIDER: S-EPMC3979566 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature