Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection.

ABSTRACT: The development of vaccines against Staphylococcus aureus has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. T cell-derived IL-17 is one of the few known correlates of antistaphylococcoal immunity, conferring protection against S. aureus infections through its ability to promote phagocytic cell effector functions. A comprehensive understanding of the discrete T cell subsets critical for site-specific IL-17-mediated bacterial clearance will therefore be necessary to inform the development of vaccines that efficiently target cellular immunity. In this study, we have identified a population of CD44+ CD27- memory γδ T cells, expanded upon infection of C57BL/6 mice with S. aureus, which produce high levels of IL-17 and mediate enhanced bacteria

SUBMITTER: Murphy AG 

PROVIDER: S-EPMC3979672 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature