Global changes in gene expression of Barrett's esophagus compared to normal squamous esophagus and gastric cardia tissues.

ABSTRACT:

Background

Barrett's esophagus (BE) is a metaplastic precursor lesion of esophageal adenocarcinoma (EA), the most rapidly increasing cancer in western societies. While the prevalence of BE is increasing, the vast majority of EA occurs in patients with undiagnosed BE. Thus, we sought to identify genes that are altered in BE compared to the normal mucosa of the esophagus, and which may be potential biomarkers for the development or diagnosis of BE.

Design

We performed gene expression analysis using HG-U133A Affymetrix chips on fresh frozen tissue samples of Barrett's metaplasia and matched normal mucosa from squamous esophagus (NE) and gastric cardia (NC) in 40 BE patients.

Results

Using a cut off of 2-fold and P<1.12E-06 (0.05 with Bonferroni correction), we identified

SUBMITTER: Hyland PL 

PROVIDER: S-EPMC3979678 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature