Multi-centre evaluation of the Determine HIV Combo assay when used for point of care testing in a high risk clinic-based population.

ABSTRACT:

Background

Determine HIV Combo (DHC) is the first point of care assay designed to increase sensitivity in early infection by detecting both HIV antibody and antigen. We conducted a large multi-centre evaluation of DHC performance in Sydney sexual health clinics.

Methods

We compared DHC performance (overall, by test component and in early infection) with conventional laboratory HIV serology (fourth generation screening immunoassay, supplementary HIV antibody, p24 antigen and Western blot tests) when testing gay and bisexual men attending four clinic sites. Early infection was defined as either acute or recent HIV infection acquired within the last six months.

Results

Of 3,190 evaluation specimens, 39 were confirmed as HIV-positive (12 with early infection) and 3,133 we

SUBMITTER: Conway DP 

PROVIDER: S-EPMC3979750 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature