Parkinson's disease and risk of fracture: a meta-analysis of prospective cohort studies.

ABSTRACT:

Backgrounds/objective

Parkinson's disease (PD) is the second most common neurodegenerative disease among the elderly population. However, epidemiological evidence on the relationship of PD with risk of fracture has not been systematically assessed. Therefore, we performed this meta-analysis of prospective studies to explore the association between PD and risk of fracture.

Methods

PubMed, Embase, Web of Science and Cochrane Library up to February 26, 2014 were searched to identify eligible studies. Random-effects model was used to pool the results.

Results

Six studies that totally involved 69,387 participants were included for analysis. Overall, PD patients had an increased risk of fracture compared with control subjects (pooled hazard ratio = 2.66, 95% confidence inte

SUBMITTER: Tan L 

PROVIDER: S-EPMC3979831 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature