The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter.

ABSTRACT: Enhancing the ability of either endogenous or transplanted oligodendrocyte progenitors (OPs) to engage in myelination may constitute a novel therapeutic approach to demyelinating diseases of the brain. It is known that in adults neural progenitors situated in the subventricular zone of the lateral ventricle (SVZ) are capable of generating OPs which can migrate into white matter tracts such as the corpus callosum (CC). We observed that progenitor cells in the SVZ of adult mice expressed CXCR4 chemokine receptors and that the chemokine SDF-1/CXCL12 was expressed in the CC. We therefore investigated the role of chemokine signaling in regulating the migration of OPs into the CC following their transplantation into the lateral ventricle. We established OP cell cultures from Olig2-EGFP mouse bra

SUBMITTER: Banisadr G 

PROVIDER: S-EPMC3979928 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature