'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption'.

ABSTRACT: Disruption of adenylyl cyclase type 5 (AC5) knockout (KO) is a novel model for longevity. Because malignancy is a major cause of death and reduced lifespan in mice, the goal of this investigation was to examine the role of AC5KO in protecting against cancer. There have been numerous discoveries in genetically engineered mice over the past several decades, but few have been translated to the bedside. One major reason is that it is difficult to alter a gene in patients, but rather a pharmacological approach is more appropriate. The current investigation employs a parallel construction to examine the extent to which inhibiting AC5, either in a genetic knockout (KO) or by a specific pharmacological inhibitor protects against cancer. This study is unique, not only because a combined genetic and

SUBMITTER: De Lorenzo MS 

PROVIDER: S-EPMC3980454 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature