Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.

ABSTRACT:

Objective

Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE produces acute hippocampal injury that evolves to HS.

Methods

FEBSTAT and 2 affiliated studies prospectively recruited 226 children aged 1 month to 6 years with FSE and controls with simple febrile seizures. All had acute magnetic resonance imaging (MRI), and follow-up MRI was obtained approximately 1 year later in the majority. Visual interpretation by 2 neuroradiologists informed only of subject age was augmented by hippocampal volumetrics, analysis of the intrahippocampal distribution of T2 signal, and apparent diffusion coefficients.

Results

Hippocampal T2 hyperintensity, maximum in

SUBMITTER: Lewis DV 

PROVIDER: S-EPMC3980500 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature