Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.

ABSTRACT:

Background

Transfusion of human blood stored for more than 2 weeks is associated with increased mortality and morbidity. During storage, packed erythrocytes progressively release hemoglobin, which avidly binds nitric oxide. We hypothesized that the nitric oxide mediated hyperemic response after ischemia would be reduced after transfusion of packed erythrocytes stored for 40 days.

Methods and results

We conducted a crossover randomized interventional study, enrolling 10 healthy adults. Nine volunteers completed the study. Each volunteer received one unit of 40-day and one of 3-day stored autologous leukoreduced packed erythrocytes, on different study days according to a randomization scheme. Blood withdrawal and reactive hyperemia index measurements were performed before and

SUBMITTER: Berra L 

PROVIDER: S-EPMC3980575 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature