Kidney injury, stem cells and regeneration.

ABSTRACT:

Purpose of review

The review summarizes the most recent advances in stem cell and regenerative approaches to treat kidney injury, and highlights areas of active controversy. Over the past year, a number of findings have been reported that have brought this field much closer to clinical translation.

Recent findings

Recent progress in regenerative nephrology includes the directed differentiation of embryonic stem cells to kidney fates, understanding the proliferative capacity of tubules after injury, the use of mesenchymal stem cells for kidney disease and tissue engineering approaches to renal replacement. Controversies persist, however, including whether adult epithelial stem cells exist at all, the best therapeutic strategy for the treatment of kidney injury and how to use

SUBMITTER: Humphreys BD 

PROVIDER: S-EPMC3980673 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature