Multimodal MRI-based Imputation of the Aβ+ in Early Mild Cognitive Impairment.

ABSTRACT:

Objective

To identify brain atrophy from structural-MRI and cerebral blood flow(CBF) patterns from arterial spin labeling perfusion-MRI that are best predictors of the Aβ-burden, measured as composite ¹⁸F-AV45-PET uptake, in individuals with early mild cognitive impairment(MCI). Furthermore, to assess the relative importance of imaging modalities in classification of Aβ+/Aβ- early mild cognitive impairment.

Methods

Sixty-seven ADNI-GO/2 participants with early-MCI were included. Voxel-wise anatomical shape variation measures were computed by estimating the initial diffeomorphic mapping momenta from an unbiased control template. CBF measures normalized to average motor cortex CBF were mapped onto the template space. Using partial least squares regression, we identi

SUBMITTER: Tosun D 

PROVIDER: S-EPMC3981105 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature