Proteomic analysis of saliva in HIV-positive heroin addicts reveals proteins correlated with cognition.

ABSTRACT: The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite effective antiretroviral therapies. Multiple etiologies have been proposed over the last several years to account for this phenomenon, including the neurotoxic effects of antiretrovirals and co-morbid substance abuse; however, no underlying molecular mechanism has been identified. Emerging evidence in several fields has linked the gut to brain diseases, but the effect of the gut on the brain during HIV infection has not been explored. Saliva is the most accessible gut biofluid, and is therefore of great scientific interest for diagnostic and prognostic purposes. This study presents a longitudinal, liquid chromatography-mass spectrometry-based quantitative proteomics study investigating saliva samples take

SUBMITTER: Dominy SS 

PROVIDER: S-EPMC3981673 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature