Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?

ABSTRACT: Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations. Evidence suggests that common genetic variants play an important role in liability to both schizophrenia and bipolar disorder. Here we tested the hypothesis that these common variants would also influence psychotic experiences measured dimensionally in adolescents in the general population. Our aim was to test whether schizophrenia and bipolar disorder polygenic risk scores (PRS), as well as specific single nucleotide polymorphisms (SNPs) previously identified as risk variants for schizophrenia, were associated with adolescent dimension-specific psychotic experiences. Self-reported Paranoia, Hallucinations, Co

SUBMITTER: Sieradzka D 

PROVIDER: S-EPMC3981778 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature