Ontology highlight
ABSTRACT:
SUBMITTER: Ge H
PROVIDER: S-EPMC3981784 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ge Hu H Liu Ge G Xiang Yang-Fei YF Wang Yu Y Guo Chao-Wan CW Chen Nan-Hao NH Zhang Ying-Jun YJ Wang Yi-Fei YF Kitazato Kaio K Xu Jun J
PloS one 20140409 4
Hemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA) in vitro and in silico. We found that (1) star-shaped pGG analogs exhibit HA-inhibition activity by interacting with the conserved structural elements of the receptor binding domain (RBD); (2) HA inhibit ...[more]