Satiety mechanisms in genetic risk of obesity.

ABSTRACT:

Importance

A better understanding of the cause of obesity is a clinical priority. Obesity is highly heritable, and specific genes are being identified. Discovering the mechanisms through which obesity-related genes influence weight would help pinpoint novel targets for intervention. One potential mechanism is satiety responsiveness. Lack of satiety characterizes many monogenic obesity disorders, and lower satiety responsiveness is linked with weight gain in population samples.

Objective

To test the hypothesis that satiety responsiveness is an intermediate behavioral phenotype associated with genetic predisposition to obesity in children.

Design, setting, and participants

Cross-sectional observational study of a population-based cohort of twins born January 1, 1994, to

SUBMITTER: Llewellyn CH 

PROVIDER: S-EPMC3981891 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature