Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation.

ABSTRACT:

Background

Little is known about the mechanisms underlying the transition from paroxysmal to persistent atrial fibrillation (AF). In an ovine model of long-standing persistent AF we tested the hypothesis that the rate of electric and structural remodeling, assessed by dominant frequency (DF) changes, determines the time at which AF becomes persistent.

Methods and results

Self-sustained AF was induced by atrial tachypacing. Seven sheep were euthanized 11.5±2.3 days after the transition to persistent AF and without reversal to sinus rhythm; 7 sheep were euthanized after 341.3±16.7 days of long-standing persistent AF. Seven sham-operated animals were in sinus rhythm for 1 year. DF was monitored continuously in each group. Real-time polymerase chain reaction, Western blotting, p

SUBMITTER: Martins RP 

PROVIDER: S-EPMC3981906 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature