Determinants of viremia copy-years in people with HIV/AIDS after initiation of antiretroviral therapy.

ABSTRACT:

Background

Recent studies suggest higher cumulative HIV viremia exposure measured as viremia copy-years (VCY) is associated with increased all-cause mortality. The objectives of this study are (1) report the association between VCY and all-cause mortality and (2) assess associations between common patient characteristics and VCY.

Methods

Analyses were based on patients recruited to the Australian HIV Observational Database (AHOD) who had received ≥24 weeks of antiretroviral therapy (ART). We established VCY after 1, 3, 5, and 10 years of ART by calculating the area under the plasma viral load time series. We used survival methods to determine the association between high VCY and all-cause mortality. We used multivariable mixed-effect models to determine predictors of VCY. We

SUBMITTER: Wright ST 

PROVIDER: S-EPMC3981928 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature