Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response.

ABSTRACT: Rhomboid domain containing 2 (RHBDD2) was previously observed overexpressed and amplified in breast cancer samples. In order to identify biological pathways modulated by RHBDD2, gene expression profiles of RHBDD2 silenced breast cancer cells were analyzed using whole genome human microarray. Among the statistically significant overrepresented biological processes, we found protein metabolism—with the associated ontological terms folding , ubiquitination, and proteosomal degradation—cell death, cell cycle, and oxidative phosphorylation. In addition, we performed an in silico analysis searching for RHBDD2 co-expressed genes in several human tissues. Interestingly, the functional analysis of these genes showed similar results to those obtained with the microarray data, with negative regulatio

SUBMITTER: Lacunza E 

PROVIDER: S-EPMC3982031 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature