Large-scale resting state network correlates of cognitive impairment in Parkinson's disease and related dopaminergic deficits.

ABSTRACT: Cognitive impairment is a common non-motor feature of Parkinson's disease (PD). Understanding the neural mechanisms of this deficit is crucial for the development of efficient methods for treatment monitoring and augmentation of cognitive functions in PD patients. The current study aimed to investigate resting state fMRI correlates of cognitive impairment in PD from a large-scale network perspective, and to assess the impact of dopamine deficiency on these networks. Thirty PD patients with resting state fMRI were included from the Parkinson's Progression Marker Initiative (PPMI) database. Eighteen patients from this sample were also scanned with (123)I-FP-CIT SPECT. A standardized neuropsychological battery was administered, evaluating verbal memory, visuospatial, and executive cognitive d

SUBMITTER: Lebedev AV 

PROVIDER: S-EPMC3982053 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature