Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.

ABSTRACT:

Purpose

In preclinical cancer studies, non-invasive functional imaging has become an important tool to assess tumor development and therapeutic effects. Tumor hypoxia is closely associated with tumor aggressiveness and is therefore a key parameter to be monitored. Recently, photoacoustic (PA) imaging with inherently co-registered high-frequency ultrasound (US) has reached preclinical applicability, allowing parallel collection of anatomical and functional information. Dual-wavelength PA imaging can be used to quantify tissue oxygen saturation based on the absorbance spectrum differences between hemoglobin and deoxyhemoglobin.

Experimental design

A new bi-modal PA/US system for small animal imaging was employed to test feasibility and reliability of dual-wavelength PA for mea

SUBMITTER: Gerling M 

PROVIDER: S-EPMC3982131 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature