The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling.

ABSTRACT: A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium that produces the Drosophila adult trachea, the homeobox transcription factor Cut regulates both growth and patterning, and its effects depend on its abundance. Quantification of the abundance of Cut in the developing airway progenitors during late larval stage 3 revealed that the cells of the developing trachea had different amounts of Cut, with the most proliferative region having an intermediate amount of Cut and the region lacking Cut exhibiting differentiation. By manipulating Cut abundance, we showed that Cut functioned in different regions to regulate proliferation o

SUBMITTER: Pitsouli C 

PROVIDER: S-EPMC3982146 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature