Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7.

ABSTRACT: γδ T cells continuously survey extralymphoid tissues, providing key effector functions during infection and inflammation. Despite their importance, the function and the molecules that drive migration of skin-recirculating γδ T cells are poorly described. Here we found that γδ T cells traveling in the skin-draining afferent lymph of sheep are effectors that produce IFN-γ or IL-17 and express high levels of the skin- and inflammation-seeking molecule E-selectin ligand. Consistent with a role for chemokine receptor CCR7 in mediating T cell exit from extralymphoid tissues, conventional CD4 and CD8T cells in skin-draining lymph were enriched in their expression of CCR7 compared to their skin-residing counterparts. In contrast, co-isolated γδ T cells in skin or lymph lacked expression of CCR7, i

SUBMITTER: Geherin SA 

PROVIDER: S-EPMC3982400 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature