Allosteric modulation of protein oligomerization: an emerging approach to drug design.

ABSTRACT: Many disease-related proteins are in equilibrium between different oligomeric forms. The regulation of this equilibrium plays a central role in maintaining the activity of these proteins in vitro and in vivo. Modulation of the oligomerization equilibrium of proteins by molecules that bind preferentially to a specific oligomeric state is emerging as a potential therapeutic strategy that can be applied to many biological systems such as cancer and viral infections. The target proteins for such compounds are diverse in structure and sequence, and may require different approaches for shifting their oligomerization equilibrium. The discovery of such oligomerization-modulating compounds is thus achieved based on existing structural knowledge about the specific target proteins, as well as on thei

SUBMITTER: Gabizon R 

PROVIDER: S-EPMC3982530 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature