Increased burden of cardiovascular disease in carriers of APOL1 genetic variants.

ABSTRACT:

Rationale

Two distinct alleles in the gene encoding apolipoprotein L1 (APOL1), a major component of high-density lipoprotein, confer protection against Trypanosoma brucei rhodesiense infection and also increase risk for chronic kidney disease. Approximately 14% of Americans with African ancestry carry 2 APOL1 risk alleles, accounting for the high chronic kidney disease burden in this population.

Objective

We tested whether APOL1 risk alleles significantly increase risk for atherosclerotic cardiovascular disease (CVD) in African Americans.

Methods and results

We sequenced APOL1 in 1959 randomly selected African American participants in the Jackson Heart Study (JHS) and evaluated associations between APOL1 genotypes and renal and cardiovascular phenotypes. Previously id

SUBMITTER: Ito K 

PROVIDER: S-EPMC3982584 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature