Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock.

ABSTRACT:

Background

The current consensus definition of septic shock requires hypotension after adequate fluid challenge or vasopressor requirement. Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue dysoxic shock), whereas others have hypotension alone with normal lactate (vasoplegic shock).

Objective

The objective of this study was to determine differences in outcomes of patients with tissue dysoxic versus vasoplegic septic shock.

Methods

This was a secondary analysis of a large, multicenter randomized controlled trial. Inclusion criteria were suspected infection, two or more systemic inflammatory response criteria, and systolic blood pressure less than 90 mmHg after a fluid bolus. Patients were categorized by presence

SUBMITTER: Sterling SA 

PROVIDER: S-EPMC3982587 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature