Causes and consequences of genetic background effects illuminated by integrative genomic analysis.

ABSTRACT: The phenotypic consequences of individual mutations are modulated by the wild-type genetic background in which they occur. Although such background dependence is widely observed, we do not know whether general patterns across species and traits exist or about the mechanisms underlying it. We also lack knowledge on how mutations interact with genetic background to influence gene expression and how this in turn mediates mutant phenotypes. Furthermore, how genetic background influences patterns of epistasis remains unclear. To investigate the genetic basis and genomic consequences of genetic background dependence of the scalloped(E3) allele on the Drosophila melanogaster wing, we generated multiple novel genome-level datasets from a mapping-by-introgression experiment and a tagged RNA gene ex

SUBMITTER: Chandler CH 

PROVIDER: S-EPMC3982700 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature