Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.

ABSTRACT:

Background

Earlier work identified specific tumor-promoting abnormalities that are shared between lung cancers and adjacent normal bronchial epithelia. We sought to characterize the yet unknown global molecular and adjacent airway field cancerization (FC) in early-stage non-small cell lung cancer (NSCLC).

Methods

Whole-transcriptome expression profiling of resected early-stage (I-IIIA) NSCLC specimens (n = 20) with matched tumors, multiple cytologically controlled normal airways with varying distances from tumors, and uninvolved normal lung tissues (n = 194 samples) was performed using the Affymetrix Human Gene 1.0 ST platform. Mixed-effects models were used to identify differentially expressed genes among groups. Ordinal regression analysis was performed to characterize sit

SUBMITTER: Kadara H 

PROVIDER: S-EPMC3982778 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature