Long-duration ventricular fibrillation exhibits 2 distinct organized states.

ABSTRACT:

Background

Previous studies showed that endocardial activation during long-duration ventricular fibrillation (VF) exhibits organized activity. We identified and quantified the different types of organized activity.

Methods and results

Two 64-electrode basket catheters were inserted, respectively, into the left ventricle and right ventricle of dogs to record endocardial activation from the endocardium during 7 minutes of VF (controls, n=6). The study was repeated with the K(ATP) channel opener pinacidil (n=6) and the calcium channel blocker flunarizine (n=6). After 2 minutes of VF without drugs, 2 highly organized left ventricular endocardial activation patterns were observed: (1) ventricular electric synchrony pattern, in which endocardial activation arose focally and either

SUBMITTER: Li L 

PROVIDER: S-EPMC3982786 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature