Sepsis from the gut: the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections.

ABSTRACT:

Background

Late-onset sepsis is a major problem in neonatology, but the habitat of the pathogens before bloodstream invasion occurs is not well established.

Methods

We examined prospectively collected stools from premature infants with sepsis to find pathogens that subsequently invaded their bloodstreams, and sought the same organisms in stools of infants without sepsis. Culture-based techniques were used to isolate stool bacteria that provisionally matched the bloodstream organisms, which were then genome sequenced to confirm or refute commonality.

Results

Of 11 children with late-onset neonatal bloodstream infections, 7 produced at least 1 stool that contained group B Streptococcus (GBS), Serratia marcescens, or Escherichia coli before their sepsis episode with prov

SUBMITTER: Carl MA 

PROVIDER: S-EPMC3982840 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature