Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.

ABSTRACT:

Background

Patients with isolated locoregional recurrences (ILRR) of breast cancer have a high risk of distant metastasis and death from breast cancer. We aimed to establish whether adjuvant chemotherapy improves the outcome of such patients.

Methods

The CALOR trial was a pragmatic, open-label, randomised trial that accrued patients with histologically proven and completely excised ILRR after unilateral breast cancer who had undergone a mastectomy or lumpectomy with clear surgical margins. Eligible patients were enrolled from hospitals worldwide and were centrally randomised (1:1) to chemotherapy (type selected by the investigator; multidrug for at least four courses recommended) or no chemotherapy, using permuted blocks, and stratified by previous chemotherapy, oestrogen-re

SUBMITTER: Aebi S 

PROVIDER: S-EPMC3982874 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature