Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.

ABSTRACT:

Background

Senescent cells, which express p16 (INK4a) , accumulate with aging and contribute to age-related pathology. To understand whether cytotoxic agents promote molecular aging, we measured expression of p16 (INK4a) and other senescence markers in breast cancer patients treated with adjuvant chemotherapy.

Methods

Blood and clinical information were prospectively obtained from 33 women with stage I to III breast cancer at four time points: before anthracycline-based chemotherapy, immediately after anthracycline-based chemotherapy, 3 months after anthracycline-based chemotherapy, and 12 months after anthracycline-based chemotherapy. Expression of senescence markers p16 (INK4a) and ARF mRNA was determined using TaqMan quantitative reverse-transcription polymerase chain rea

SUBMITTER: Sanoff HK 

PROVIDER: S-EPMC3982894 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature