Low-dose formaldehyde delays DNA damage recognition and DNA excision repair in human cells.

ABSTRACT:

Objective

Formaldehyde is still widely employed as a universal crosslinking agent, preservative and disinfectant, despite its proven carcinogenicity in occupationally exposed workers. Therefore, it is of paramount importance to understand the possible impact of low-dose formaldehyde exposures in the general population. Due to the concomitant occurrence of multiple indoor and outdoor toxicants, we tested how formaldehyde, at micromolar concentrations, interferes with general DNA damage recognition and excision processes that remove some of the most frequently inflicted DNA lesions.

Methodology/principal findings

The overall mobility of the DNA damage sensors UV-DDB (ultraviolet-damaged DNA-binding) and XPC (xeroderma pigmentosum group C) was analyzed by assessing real-time pr

SUBMITTER: Luch A 

PROVIDER: S-EPMC3983121 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature