Histone deacetylase 1 and p300 can directly associate with chromatin and compete for binding in a mutually exclusive manner.

ABSTRACT: Lysine acetyltransferases (KATs) and histone deacetylases (HDACs) are important epigenetic modifiers and dynamically cycled on active gene promoters to regulate transcription. Although HDACs are recruited to gene promoters and DNA hypersensitive sites through interactions with DNA binding factors, HDAC activities are also found globally in intergenic regions where DNA binding factors are not present. It is suggested that HDACs are recruited to those regions through other distinct, yet undefined mechanisms. Here we show that HDACs can be directly recruited to chromatin in the absence of other factors through direct interactions with both DNA and core histone subunits. HDACs interact with DNA in a non-sequence specific manner. HDAC1 and p300 directly bind to the overlapping regions of the hi

SUBMITTER: Li X 

PROVIDER: S-EPMC3983199 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature